|
KMID : 0881720150300020202
|
|
Journal of Food Hygiene and Safety
2015 Volume.30 No. 2 p.202 ~ p.209
|
|
|
Protective Effects of Capsosiphon fulvescens and Pheophorbide a on Streptozotocin-induced Oxidative Stress in Testicular
|
|
Son Won-rak
Nam Mi-Hyun
Han Ah-Ram
Pyo Min-Cheol
Kim Se-Wook
Jung Hye-Lim
Lee Hwa
Kim Ji-Yeon
Lee Kwang-Won
|
|
|
Abstract
|
|
|
|
We investigated the effect of Capsosiphon fulvescens (CFE) and pheophorbide a (PhA) contained in CFE on oxidative stress regarded as a factor for diabetic complication. Streptozotocin (STZ), known as an oxidative stress inducer, was intraperitoneal injected for causing diabetes. After 7 days, CFE (4 and 20 mg/kg body weight) and PhA (0.2 mg/kg body weight) were treated once a day for 9 weeks. After the sacrifice, testis tissues were collected for the experiments. We confirmed that the treatment with CFE and PhA in diabetic animals not only decreased level of lipid peroxidation and serum nitric oxide compared with the diabetes group, but also the activities of glutathione peroxidase and glutathione-S-transferase were restored remarkably. Furthermore the activity of antioxidant enzymes, catalase and superoxide dismutase, were significantly recovered. With these results, our study suggest that CFE containing PhA may prevent seminal glands damages induced by oxidative stress in diabetic condition.
|
|
|
KEYWORD
|
|
|
Capsosiphon fulvescens, pheoporbide a, testis dysfunction, oxidative stress, antioxidant enzymes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|